Scientists have developed a
new method for fighting cancer that involves unleashing killer stem
cells specially created to fight the disea
A team of researchers from Massachusetts General
Hospital and the Harvard Stem Cell Institute have successfully tested
the method on mice and published the findings
in the journal Stem Cells. By engineering stem cells to secrete a toxin
that kills cancer cells, they were able to remove brain cancer from the
mice without harming any healthy cells.
"Cancer-killing toxins have been used with great
success in a variety of blood cancers, but they don't work as well in
solid tumours because the cancers aren't as accessible and the toxins
have a short half-life," lead author Khalid Shah told BBC News. "Now, we have toxin-resistant stem cells that can make and release cancer-killing drugs."
In other words, if this method proves successful,
doctors may actually be able to target cancer cells — and only cancer
cells — to destroy them while leaving others unharmed, which would be a
major revolution in the field of cancer treatment.
How it works: The researchers
first took mice with brain cancer and surgically removed their tumors.
They then extracted the genetically engineered stem cells, which were
placed at the former tumor site in the form of a gel.
Because the stem cells were designed to produce a
toxin that kills cancer cells, the big challenge was making sure the
toxin didn't kill healthy brain cells or other stem cells. Luckily, this
part was a success, and this success is what makes this potential
treatment method so exciting.
The next step, Shah said, is to try the process using different types of cancers. He told BBC News he hopes there can be clinical trials in the next five years.
What it means: This doesn't mean we can now
cure brain cancer, since the technique has yet to be tested on humans
and will likely require plenty of work before it can be used outside of a
laboratory environment.
Still, this is good news. The deadly and
complex disease that it is, finding any new and promising method to
fight cancer is always a step in the right direction. And from the
initial findings of this stem cell treatment method, experts are calling
this a major step in cancer treatment research.
"This is a clever study, which signals
the beginning of the next wave of therapies," Chris Mason, professor of
regenerative medicine at University College London, told BBC News. "Cells can do so much. This is the way the future is going to be."
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